MECHANISM OF GRASS-POLLEN-INDUCED ASTHMA

被引:311
作者
SUPHIOGLU, C
SINGH, MB
TAYLOR, P
BELLOMO, R
HOLMES, P
PUY, R
KNOX, RB
机构
[1] UNIV MELBOURNE,SCH BOT,PARKVILLE,VIC 3052,AUSTRALIA
[2] MONASH MED CTR,DEPT RESP MED,CLAYTON,VIC,AUSTRALIA
[3] ALFRED HOSP,ALLERGY & RESP IMMUNOL UNIT,PRAHRAN,VIC 3181,AUSTRALIA
基金
英国医学研究理事会;
关键词
D O I
10.1016/0140-6736(92)90864-Y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many asthmatics are sensitive to rye-grass pollen, but pollen grains are too large to penetrate the lower airways. Our aim was to investigate the mechanism by which rye-grass pollen causes asthma. A major allergen of rye-grass pollen, Lol pIX, is located in intracellular starch granules within pollen grains. In-vitro tests showed that pollen grains are ruptured in rainwater by osmotic shock, each grain releasing about 700 starch granules into the environment. These granules are small enough to enter the airways (< 3-mu-m in diameter). The starch granules were present in atmospheric samples taken during the pollen season, and showed a 50-fold increase in atmospheric concentration on days following rainfall. Isolated granules elicited IgE-mediated responses in asthmatic patients, and 4 patients with rainfall-associated asthma who underwent an inhalation challenge test had striking bronchial constriction after exposure to starch granules. Starch granules released from rye-grass pollen seem to be capable of causing asthma.
引用
收藏
页码:569 / 572
页数:4
相关论文
共 10 条
[1]  
BELLOMO R, IN PRESS MED J AUST
[2]   CHILDHOOD ASTHMA AND GRASS-POLLEN AEROBIOLOGY IN MELBOURNE [J].
HILL, DJ ;
SMART, IJ ;
KNOX, RB .
MEDICAL JOURNAL OF AUSTRALIA, 1979, 1 (10) :426-429
[3]   IMMUNODETECTION METHODS FOR GRASS-POLLEN ALLERGENS ON WESTERN BLOTS [J].
ONG, EK ;
SUPHIOGLU, C ;
SINGH, MB ;
KNOX, RB .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1990, 93 (04) :338-343
[4]  
PACKE GE, 1985, LANCET, V2, P199
[5]  
PAGGIARO PL, 1990, RESPIRATION, V57, P51
[6]  
SALVAGGIO JE, 1967, J ALLERGY, V30, P227
[7]   ISOLATION OF CDNA-ENCODING A NEWLY IDENTIFIED MAJOR ALLERGENIC PROTEIN OF RYE-GRASS POLLEN - INTRACELLULAR TARGETING TO THE AMYLOPLAST [J].
SINGH, MB ;
HOUGH, T ;
THEERAKULPISUT, P ;
AVJIOGLU, A ;
DAVIES, S ;
SMITH, PM ;
TAYLOR, P ;
SIMPSON, RJ ;
WARD, LD ;
MCCLUSKEY, J ;
PUY, R ;
KNOX, RB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1384-1388
[8]   EVIDENCE OF GRASS-POLLEN ALLERGENIC ACTIVITY IN THE SMALLER MICRONIC ATMOSPHERIC AEROSOL FRACTION [J].
SPIEKSMA, FTM ;
KRAMPS, JA ;
VANDERLINDEN, AC ;
NIKKELS, BH ;
PLOMP, A ;
KOERTEN, HK ;
DIJKMAN, JH .
CLINICAL AND EXPERIMENTAL ALLERGY, 1990, 20 (03) :273-280
[9]   SUBMICRONIC AIRBORNE ALLERGENS [J].
STEWART, GA ;
HOLT, PG .
MEDICAL JOURNAL OF AUSTRALIA, 1985, 143 (09) :426-427
[10]   DEPOSITION OF INHALED POLLEN AND POLLEN EXTRACT IN HUMAN AIRWAYS [J].
WILSON, AF ;
NOVEY, HS ;
BERKE, RA ;
SURPRENANT, EL .
NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (20) :1056-1058