THE TOXICITY OF MPTP TO DOPAMINE NEURONS IN CULTURE IS REDUCED AT HIGH-CONCENTRATIONS

被引：38

作者：

FRIEDMAN, L ^{[1
]}

MYTILINEOU, C ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,DEPT NEUROL,NEW YORK,NY 10029

来源：

NEUROSCIENCE LETTERS | 1987年 / 79卷 / 1-2期

关键词：

D O I：

10.1016/0304-3940(87)90673-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：65 / 72

页数：8

共 19 条

[1] THE NEUROTOXIC ACTIONS OF 6-HYDROXYDOPAMINE INFUSED INTO THE RAT SUBSTANTIA-NIGRA [J].

BRADBURY, AJ ;

COSTALL, B ;

DOMENEY, AM ;

JENNER, PJ ;

MARSDEN, CD ;

NAYLOR, RJ .

NEUROSCIENCE LETTERS, 1986, 67 (02) :208-212

[2] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BURNS, RS ;

CHIUEH, CC ;

MARKEY, SP ;

EBERT, MH ;

JACOBOWITZ, DM ;

KOPIN, IJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550

[3] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[4]

CHIUEH CC, 1984, EUR J PHARMACOL, V100, P189, DOI 10.1016/0014-2999(84)90221-8

[5] PARGYLINE AND DEPRENYL PREVENT THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) IN MONKEYS [J].

COHEN, G ;

PASIK, P ;

COHEN, B ;

LEIST, A ;

MYTILINEOU, C ;

YAHR, MD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (01) :209-210

[6] CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].

DAVIS, GC ;

WILLIAMS, AC ;

MARKEY, SP ;

EBERT, MH ;

CAINE, ED ;

REICHERT, CM ;

KOPIN, IJ .

PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254

[7]

FULLER RW, 1985, J PHARMACOL EXP THER, V232, P696

[8] MONOAMINE-OXIDASE B(MAO-B) IS THE MAJOR CATALYST FOR 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) OXIDATION IN HUMAN-BRAIN AND OTHER TISSUES [J].

GLOVER, V ;

GIBB, C ;

SANDLER, M .

NEUROSCIENCE LETTERS, 1986, 64 (02) :216-220

[9] BEHAVIORAL PROPERTIES OF GBR-12909, GBR-13069 AND GBR-13098 - SPECIFIC INHIBITORS OF DOPAMINE UPTAKE [J].

HEIKKILA, RE ;

MANZINO, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 103 (3-4) :241-248

[10] DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].

HEIKKILA, RE ;

HESS, A ;

DUVOISIN, RC .

SCIENCE, 1984, 224 (4656) :1451-1453

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