REGULATION OF VIRULENCE BY ENVIRONMENTAL SIGNALS IN GROUP-A STREPTOCOCCI - INFLUENCE OF OSMOLARITY, TEMPERATURE, GAS-EXCHANGE, AND IRON LIMITATION ON EMM TRANSCRIPTION

被引：74

作者：

MCIVER, KS ^{[1
]}

HEATH, AS ^{[1
]}

SCOTT, JR ^{[1
]}

机构：

[1] EMORY UNIV,DEPT IMMUNOL & MICROBIOL,ATLANTA,GA 30322

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 11期

关键词：

D O I：

10.1128/IAI.63.11.4540-4542.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription of the gene encoding the antiphagocytic M protein (emm) of the group A streptococci has been shown to be regulated by CO2 (M. G. Caparon, R. T. Geist, J. Perez-Casal, and J. R. Scott, J. Bacteriol. 174:5693-5701, 1992). We tested the influence of additional environmental growth conditions on emm expression. Increased osmolarity, low temperature, growth with free exchange of gasses, or the restricted availability of iron resulted in decreased transcription from the emm promoter.

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页码：4540 / 4542

页数：3

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