SYNTHESIS OF (2(R),3(S))[4-H-2(3)]VALINE - APPLICATION TO THE STUDY OF THE RING EXPANSION OF PENICILLIN-N BY DEACETOXYCEPHALOSPORIN-C SYNTHASE FROM STREPTOMYCES-CLAVULIGERUS

被引：9

作者：

BALDWIN, JE ^{[1
]}

ADLINGTON, RM ^{[1
]}

CROUCH, NP ^{[1
]}

MELLOR, LC ^{[1
]}

MORGAN, N ^{[1
]}

SMITH, AM ^{[1
]}

SUTHERLAND, JD ^{[1
]}

机构：

[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 14期

关键词：

D O I：

10.1016/0040-4020(95)00126-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of (<2(R)under bar>,<3(S)under bar>)[4-H-2(3)] valine was developed, and used to synthesise (<2(R)under bar>) [2'-H-2(3)]-penicillin N via a chemico-enzymatic synthesis. This labelled penicillin was then used to demonstrate the stereospecific ring expansion of penicillin N to deacetoxycephalosporin C by deacetoxycephalosporin C synthase from Streptomyces clavuligerus.

引用

页码：4089 / 4100

页数：12

共 25 条

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