PALLADIUM-CATALYZED SYNTHESIS OF SPIROINDOLINES

被引:93
作者
GRIGG, R [1 ]
FRETWELL, P [1 ]
MEERHOLTZ, C [1 ]
SRIDHARAN, V [1 ]
机构
[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)80760-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of palladium catalysed consecutive bis(5-exo trig)-, 5-exo trig-6-exo trig-, and 5-exo trig-7-endo trig-cyclisations via an alkene relay onto benzene or a wide range of heterocycles (pyrrole, furan, thiophen, indole, pyridine, pyridones) generates 5,5-, 5,6- and 5,7-spiroindolines in good yield.
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页码:359 / 370
页数:12
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