METALATION OF DIAZINES .8. METALATION OF 4-CHLOROPYRIMIDINE DERIVATIVES - NEW SYNTHESIS OF TRIMETHOPRIM

被引：25

作者：

PLE, N ^{[1
]}

TURCK, A ^{[1
]}

MARTIN, P ^{[1
]}

BARBEY, S ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] IRCOF INSA,CHIM ORGAN FINE & HETEROCYCL LAB,CNRS,URA 1429,BP 08,F-76131 MONT ST AIGNAN,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 10期

关键词：

TRIMETHOPRIM; SYNTHESIS; PYRIMIDINE; METALATION; REGIOSELECTIVITY;

D O I：

10.1016/0040-4039(93)85019-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of trimethoprim is described; metalation of a pyrimidine has been used in the key step. An exceptional regioselectivity in the metalation of pyrimidine derivatives has been highlighted.

引用

页码：1605 / 1608

页数：4

共 8 条

[1] BISAGNI E, 1988, HETEROCYCLES, V27, P1674
[2] METALATION OF DIAZINES .3. NEW SYNTHESIS OF ANALOGS OF TRIMETHOPRIM AND OF BACIMETHRIN
PLE, N
TURCK, A
FIQUET, E
QUEGUINER, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (02) : 283 - 287
[3] PLE N, 1992, HETEROCYCLIC CHEM, V29, P467
[4] LITHIATION OF POLYCHLOROPYRIMIDINES AND DICHLOROPYRIDINES
RADINOV, R
CHANEV, C
HAIMOVA, M
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (15) : 4793 - 4796
[5] METALATION OF DIAZINES .4. LITHIATION OF SYM-DISUBSTITUTED PYRAZINES
TURCK, A
TROHAY, D
MOJOVIC, L
PLE, N
QUEGUINER, G
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1991, 412 (03) : 301 - 310
[6] TURCK A, 1988, SYNTHESIS-STUTTGART, P881
[7] METALATION OF DIAZINES .2. 1ST METALATION OF PYRIDAZINE, METALATION OF 2,4-DICHLOROPYRIMIDINE
TURCK, A
PLE, N
MOJOVIC, L
QUEGUINER, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (05) : 1377 - 1381
[8] TURCK A, 1992, HETEROCYCLIC CHEM, V29, P699

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