REGIOSELECTIVE HYDROLYSIS OF AROMATIC DINITRILES USING A WHOLE-CELL CATALYST

被引：80

作者：

CROSBY, J

MOILLIET, J

PARRATT, JS

TURNER, NJ

机构：

[1] UNIV EXETER, DEPT CHEM, EXETER EX4 4QD, DEVON, ENGLAND

[2] ZENECA FINE CHEM MFG ORG, DEPT PROC TECHNOL, HUDDERSFIELD HD2 1FF, W YORKSHIRE, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 13期

关键词：

D O I：

10.1039/p19940001679

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of aromatic dinitriles have been; examined as substrates for an immobilised whole cell Rhodococcus sp. that catalyses the hydrolysis of nitriles to amides and/or carboxylic acids. The fluorinated aromatic dinitriles 48 and 49 were regioselectively hydrolysed to the corresponding cyano amides 48a and 49a whereas the non-fluorinated analogues 41-44 were converted to cyano acids but with poorer regioselectivity.

引用

页码：1679 / 1687

页数：9

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[51] CONVERSION OF 3-CYANOPYRIDINE TO NICOTINIC-ACID BY NOCARDIA-RHODOCHROUS LL100-21 [J].