ASYMMETRIC HYDROLYSIS OF A DISUBSTITUTED MALONONITRILE BY THE AID OF A MICROORGANISM

被引：44

作者：

YOKOYAMA, M ^{[1
]}

SUGAI, T ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,HIYOSHI 3-14-1,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80214-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

引用

页码：1081 / 1084

页数：4

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