ENANTIOSELECTIVE HYDROLYSIS OF NITRILES AND AMIDES USING AN IMMOBILIZED WHOLE CELL SYSTEM

被引：46

作者：

COHEN, MA ^{[1
]}

PARRATT, JS ^{[1
]}

TURNER, NJ ^{[1
]}

机构：

[1] UNIV EXETER,DEPT CHEM,EXETER EX4 4RJ,DEVON,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(00)86056-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An immobilised whole cell catalyst SP361 has been shown to hydrolyse a range of 2-alkyl arylacetonitriles 1a-3a and amides 2b, 3b with good to excellent enantioselectivity. The absolute configuration of the derived amides and/or carboxylic acids shows remarkable changes according to the structure of the nitrile substrate.

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页码：1543 / 1546

页数：4

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