ENZYMATIC-HYDROLYSIS OF PROCHIRAL DINITRILES

被引：38

作者：

CROSBY, JA

PARRATT, JS

TURNER, NJ ^{[1
]}

机构：

[1] UNIV EXETER,DEPT CHEM,STOCKER RD,EXETER EX4 4RJ,DEVON,ENGLAND

[2] ICI SPECIALTIES,MANCHESTER M9 3DA,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(00)86057-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of prochiral 3-hydroxyglutaronitrile derivatives 1-5 has been enzymically hydrolysed to the corresponding nitrile-carboxylic acids 1b-5b with enantiomeric excesses ranging from 22-84%. In all cases the products were of the (S)-configuration.

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页码：1547 / 1550

页数：4

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