STRESS, ANTIDEPRESSANT DRUGS, AND THE LOCUS-COERULEUS

被引:74
作者
BRADY, LS
机构
[1] Section on Functional Neuroanatomy, NIMH, Bethesda, MD 20892
关键词
ANTIDEPRESSANTS; CORTICOTROPIN-RELEASING HORMONE; FLUOXETINE; HYPOTHALAMUS; HIPPOCAMPUS; IDAZOXAN; IMIPRAMINE; IMMOBILIZATION; LOCUS COERULEUS; NOREPINEPHRINE; PARAVENTRICULAR NUCLEUS; PHENELZINE; STRESS; TYROSINE HYDROXYLASE;
D O I
10.1016/0361-9230(94)90168-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This review presents a synthesis of a large body of seemingly inconsistent literature on the role of the locus coeruleus-norepinephrine (LC-NE) system and the corticotropin-releasing hormone (CRH)-median eminence system in mediating the CNS effects of stress and the therapeutic effects of antidepressant drugs. The clinical implications of these findings for the etiology and treatment of strsss-related psychiatric disorders such as depression will be discussed.
引用
收藏
页码:545 / 556
页数:12
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