POSITIVE SELECTION OF SELFREACTIVE AND ALLOREACTIVE CD8+ T-CELLS IN TAP-1 MUTANT MICE

被引:58
作者
ALDRICH, CJ
LJUNGGREN, HG
VANKAER, L
ASHTONRICKARDT, PG
TONEGAWA, S
FORMAN, J
机构
[1] UNIV TEXAS,SW MED CTR,DEPT MICROBIOL,DALLAS,TX 75235
[2] MIT,CTR CANC RES,DEPT BIOL,CAMBRIDGE,MA 02139
[3] KAROLINSKA INST,CTR MICROBIOL & TUMORBIOL,S-17177 STOCKHOLM,SWEDEN
关键词
CYTOTOXIC T LYMPHOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDE TRANSPORTERS;
D O I
10.1073/pnas.91.14.6525
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have <1% peripheral CD8(+) T cells. We show that these -/- mite but not their +/- littermates display strong primary syngeneic anti-H-2K(b) and -D-b-specific responses mediated by CD8(+) T cells. These responses are augmented by in vivo priming. Further, -/- mice primed in vivo with H-2(d) alloantigens generate an anti-H-2(d) response which appears nearly as strong as that found in +/- littermates. Both -/- anti-H-2(b) and anti-H-2(d) T cells do not recognize target cells from Tap-1 -/- animals or Tap-2-deficient RMA-S cells. Thus, some CD8(+) anti-self and alloreactive T cells tan be selected in the absence of Tap proteins.
引用
收藏
页码:6525 / 6528
页数:4
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