1-METHYL-4-PHENYLPYRIDINIUM (MPP+) ANALOGS - INVIVO NEUROTOXICITY AND INHIBITION OF STRIATAL SYNAPTOSOMAL DOPAMINE UPTAKE

被引：26

作者：

JOHNSON, EA

WU, EY

ROLLEMA, H

BOOTH, RG

TREVOR, AJ

CASTAGNOLI, N

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143

[4] STATE UNIV GRONINGEN,DEPT MED CHEM,9700 AB GRONINGEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1989年 / 166卷 / 01期

关键词：

D O I：

10.1016/0014-2999(89)90684-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：65 / 74

页数：10

共 30 条

[1] STUDIES ON SEMIRIGID TRICYCLIC ANALOGS OF THE NIGROSTRIATAL TOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].

BOOTH, RG ;

TREVOR, A ;

SINGER, TP ;

CASTAGNOLI, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :473-477

[2] REPEATED ADMINISTRATION OF N-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE TO RATS IS NOT TOXIC TO STRIATAL DOPAMINE NEURONS [J].

BOYCE, S ;

KELLY, E ;

REAVILL, C ;

JENNER, P ;

MARSDEN, CD .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (11) :1747-1752

[3] 1-METHYL-4-PHENYLPYRIDINE IS NEUROTOXIC TO THE NIGROSTRIATAL DOPAMINE PATHWAY [J].

BRADBURY, AJ ;

COSTALL, B ;

DOMENEY, AM ;

JENNER, P ;

KELLY, ME ;

MARSDEN, CD ;

NAYLOR, RJ .

NATURE, 1986, 319 (6048) :56-57

[4] METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].

CHIBA, K ;

TREVOR, A ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578

[5] ACTIVE UPTAKE OF MPP+, A METABOLITE OF MPTP, BY BRAIN SYNAPTOSOMES [J].

CHIBA, K ;

TREVOR, AJ ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (03) :1228-1232

[6]

CHIUEH CC, 1984, EUR J PHARMACOL, V100, P189, DOI 10.1016/0014-2999(84)90221-8

[7]

Collins M A, 1987, Adv Neurol, V45, P179

[8] REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].

GLOWINSKI, J ;

IVERSEN, LL .

JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+

[9] EFFECTS OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE AND RELATED-COMPOUNDS ON THE UPTAKE OF [H-3]3,4-DIHYDROXYPHENYLETHYLAMINE AND [H-3]5-HYDROXYTRYPTAMINE IN NEOSTRIATAL SYNAPTOSOMAL PREPARATIONS [J].

HEIKKILA, RE ;

YOUNGSTER, SK ;

MANZINO, L ;

CABBAT, FS ;

DUVOISIN, RC .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) :310-313

[10] DOPAMINERGIC TOXICITY AFTER THE STEREOTAXIC ADMINISTRATION OF THE 1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) TO RATS [J].

HEIKKILA, RE ;

NICKLAS, WJ ;

DUVOISIN, RC .

NEUROSCIENCE LETTERS, 1985, 59 (01) :135-140

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