POSSIBLE INVOLVEMENT OF SUPEROXIDE ANION IN THE INDUCTION OF CYANIDE-RESISTANT RESPIRATION IN HANSENULA-ANOMALA

被引：114

作者：

MINAGAWA, N ^{[1
]}

KOGA, S ^{[1
]}

NAKANO, M ^{[1
]}

SAKAJO, S ^{[1
]}

YOSHIMOTO, A ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, PHOTON MED CTR, HAMAMATSU, JAPAN

来源：

FEBS LETTERS | 1992年 / 302卷 / 03期

关键词：

MITOCHONDRIA; SUPEROXIDE ANION; CHEMILUMINESCENCE; CYANIDE-RESISTANT RESPIRATION;

D O I：

10.1016/0014-5793(92)80444-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A chemiluminescence study showed that Q(i) site inhibitors such as antimycin A induce O2- generation in respiring cyanide-sensitive mitochondria from the yeast, Hansenula anomala. The O2- generation was suppressed by radical scavengers such as flavone, butylated hydroxyanisole, and Co0. Induction of cyanide-resistant respiration in H. anomala cells by Q(i) site inhibitors was also inhibited by these radical scavengers. Furthermore, antimycin A-induced synthesis of the mitochondrial 36-kDa protein, which is thought to be the alternative oxidase functional in the cyanide-resistant respiratory pathway, was abolished by the addition of flavone. These observations suggest that O2-, is somehow involved in the induction of cyanide-resistant respiration.

引用

页码：217 / 219

页数：3

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