CLONED ADENOSINE A(3) RECEPTORS - PHARMACOLOGICAL PROPERTIES, SPECIES-DIFFERENCES AND RECEPTOR FUNCTIONS

被引：376

作者：

LINDEN, J

机构：

[1] Joel Linden, University of Virginia Health Sciences Center, Charlottesville

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 08期

关键词：

D O I：

10.1016/0165-6147(94)90011-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, Joel Linden summarizes what is known about a new and intriguing member of the adenosine receptor family, the A(3) receptor. This receptor exhibits unusually large differences in structure, tissue distribution and pharmacological properties between species. Rat A(3) receptors are resistant to blockade by xanthine antagonists, but human and sheep A(3) receptors can be potently blocked by certain xanthines, notably acidic 8-phenylxanthines. One function of the receptor is to facilitate degranulation of mast cells, and a role for mast cells and A(3) receptors in mediating myocardial preconditioning has been proposed. Therefore, selective antagonists of A(3) receptors have potential for the treatment of allergic, inflammatory and possibly ischaemic disorders.

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收藏

页码：298 / 306

页数：9

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