OBSERVATION OF INTACT (HEME-BOUND) MYOGLOBIN BY ELECTROSPRAY IONIZATION ON A DOUBLE-FOCUSING MASS-SPECTROMETER

被引:39
作者
LOO, JA [1 ]
GIORDANI, AB [1 ]
MUENSTER, H [1 ]
机构
[1] FINNIGAN MAT GMBH,BREMEN,GERMANY
关键词
D O I
10.1002/rcm.1290070304
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A noncovalently bound complex, the heme-apomyoglobin protein system (M(r) 17 568), was detected using electrospray ionization on a double-focusing mass spectrometer with an array detector. The kilovolt energy conditions used for ion transmission and focusing did not cause significant amounts of fragmentation of the weakly-bound complex. With a high-performance array detector, femtomolar sensitivity was achieved for myoglobin in water.
引用
收藏
页码:186 / 189
页数:4
相关论文
共 27 条
  • [21] OF PROTONS OR PROTEINS - A BEAMS A BEAM FOR A THAT (BURNS,O.S.)
    MENG, CK
    MANN, M
    FENN, JB
    [J]. ZEITSCHRIFT FUR PHYSIK D-ATOMS MOLECULES AND CLUSTERS, 1988, 10 (2-3): : 361 - 368
  • [22] MIRZA UA, 1992, 40TH P C MASS SPECTR, P491
  • [23] PESCH R, 1989, 37TH P ASMS C MASS S, P1079
  • [24] PRESERVATION OF NONCOVALENT ASSOCIATIONS IN ELECTROSPRAY IONIZATION MASS-SPECTROMETRY - MULTIPLY CHARGED POLYPEPTIDE AND PROTEIN DIMERS
    SMITH, RD
    LIGHTWAHL, KJ
    WINGER, BE
    LOO, JA
    [J]. ORGANIC MASS SPECTROMETRY, 1992, 27 (07): : 811 - 821
  • [25] NEW DEVELOPMENTS IN BIOCHEMICAL MASS-SPECTROMETRY - ELECTROSPRAY IONIZATION
    SMITH, RD
    LOO, JA
    EDMONDS, CG
    BARINAGA, CJ
    UDSETH, HR
    [J]. ANALYTICAL CHEMISTRY, 1990, 62 (09) : 882 - 899
  • [26] ELECTROSPRAY IONIZATION MASS-SPECTRA OF HEMOGLOBIN AND TRANSFERRIN BY A MAGNETIC-SECTOR MASS-SPECTROMETER - COMPARISON WITH THEORETICAL ISOTOPIC DISTRIBUTIONS
    WADA, Y
    TAMURA, J
    MUSSELMAN, BD
    KASSEL, DB
    SAKURAI, T
    MATSUO, T
    [J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1992, 6 (01) : 9 - 13
  • [27] MASS-SPECTROMETRY SOFTWARE FOR BIOCHEMICAL-ANALYSIS IN ELECTROSPRAY AND FAST-ATOM-BOMBARDMENT MODES
    WATKINS, PJF
    JARDINE, I
    ZHOU, JXG
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (04) : 957 - 962