SYNUCLEIN PROTEINS AND ALZHEIMERS-DISEASE

被引：40

作者：

BROOKES, AJ

STCLAIR, D

机构：

[1] MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, Crewe Road

来源：

TRENDS IN NEUROSCIENCES | 1994年 / 17卷 / 10期

关键词：

D O I：

10.1016/0166-2236(94)90013-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Aizheimer's disease, synuclein/NAC (non-amyloid beta component of Aizheimer's disease amyloid) proteins are found in presynaptic disease, and they are also found closely linked to beta-amyloid fibrils in senile plaques. Synuclein/NAC proteins provide a potential molecular link between the degeneration of cholinergic nerve terminals, and the formation of plaques, and might have a primary role in their development.

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页码：404 / 405

页数：2

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