THYMUS-NEUROENDOCRINE INTERACTIONS IN EXTRATHYMIC T-CELL DEVELOPMENT

被引:82
作者
WANG, J
KLEIN, JR
机构
[1] UNIV TULSA, DEPT BIOL SCI, TULSA, OK 74104 USA
[2] UNIV TULSA, CTR STUDIES MOLEC BIOL & BIOTECHNOL, TULSA, OK 74104 USA
关键词
D O I
10.1126/science.8091211
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies of the development of murine intestinal intraepithelial lymphocytes (IELs) have yielded markedly different results depending on the experimental system used. In athymic radiation chimeras, IELs consist of all subsets found in euthymic mice; adult mice that were athymic at birth have only IELs that are positive for T cell receptor gamma delta and CD8 alpha alpha. These differences are resolved by the finding that administration of the neuropeptide thyrotropin-releasing hormone to adult mice thymectomized as neonates leads to the development of all IEL T cells. Thus, a neuroendocrine signal initiated by the thymus during fetal or neonatal life appears to be required for subsequent extrathymic maturation of gut alpha beta T cells.
引用
收藏
页码:1860 / 1862
页数:3
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