REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC INVESTIGATION OF LEVODOPA PREPARATIONS .1. AMINO-ACID IMPURITIES

被引：7

作者：

SCHIEFFER, GW

机构：

[1] Pharmaceutical Research Division, Norwich-Eaton Pharmaceuticals, Division of Morton-Norwich Products, inc., Norwich, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 10期

关键词：

Antiparkinsonian agents—levodopa; high‐performance liquid chromatographic analysis; amino acid impurities; commercial preparations; High‐performance liquid chromatography—analysis; levodopa; Levodopa—analysis; high‐performance liquid chromatography;

D O I：

10.1002/jps.2600681026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A reversed‐phase high‐performance liquid chromatographic procedure with UV detection at 280 nm is presented for the determination of 6‐hydroxydopa, tyrosine, 3 O‐methyldopa, and other trace amino acid impurities in levodopa preparations. The method is fast and sufficiently sensitive to determine trace impurities at 0.1% of the Jevodopa concentration with a relative standard deviation of 4‐6%. The trace impurities can be estimated at ⩽0.01%. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1296 / 1298

页数：3

共 15 条

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SCHIEFFER, GW .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (10) :1299-1301

[13] AUTOMATIC RECORDING APPARATUS FOR USE IN THE CHROMATOGRAPHY OF AMINO ACIDS [J].

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[14]

WATSON JR, 1974, J PHARM SCI, V63, P96, DOI 10.1002/jps.2600630125

[15]

1975, US PHARMACOPEIA, P280

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