2 EFFECTIVE PROCEDURES FOR THE SYNTHESIS OF TRICHLOROMETHYL KETONES, USEFUL PRECURSORS OF CHIRAL ALPHA-AMINO AND ALPHA-HYDROXY ACIDS

被引：77

作者：

COREY, EJ

LINK, JO

SHAO, Y

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)92656-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23-degrees-C followed by oxidation and the other utilizing the coupling of organozinc intermediates with trichloroacetyl chloride.

引用

页码：3435 / 3438

页数：4

共 22 条

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[2] THE DECOMPOSITION OF TRIHALOGENOACETIC ACIDS IN DIMETHYLSULFOXIDE - A MILD ROUTE FROM CARBONYL-COMPOUNDS TO TRIHALOGENOMETHYLETHANOL AND TRIHALOGENOMETHYL KETONES
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[3] BARBOZA JCD, 1985, TETRAHEDRON LETT, V26, P829
[4] 1-MESITYL-2,2,2-TRIFLUOROETHANOL, AN OUTSTANDING NEW CHIRAL CONTROLLER FOR CATALYZED DIELS-ALDER REACTIONS
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[5] AN EFFICIENT AND CATALYTICALLY ENANTIOSELECTIVE ROUTE TO (S)-(-)-PHENYLOXIRANE
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[6] A GENERAL, CATALYTIC, AND ENANTIOSELECTIVE SYNTHESIS OF ALPHA-AMINO-ACIDS
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (05) : 1906 - 1908
[7] A NEW SYSTEM FOR CATALYTIC ENANTIOSELECTIVE REDUCTION OF ACHIRAL KETONES TO CHIRAL ALCOHOLS - SYNTHESIS OF CHIRAL ALPHA-HYDROXY ACIDS
COREY, EJ
BAKSHI, RK
[J]. TETRAHEDRON LETTERS, 1990, 31 (05) : 611 - 614
[8] A CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF DENOPAMINE, A USEFUL DRUG FOR CONGESTIVE-HEART-FAILURE
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (01) : 442 - 444
[9] THE 1ST ENANTIOSELECTIVE SYNTHESES OF PURE R-ISOPROTERENOL AND S-ISOPROTERENOL
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[J]. TETRAHEDRON LETTERS, 1990, 31 (05) : 601 - 604
[10] REMARKABLY EFFECTIVE AND SIMPLE SYNTHESES OF ENANTIOMERICALLY PURE SECONDARY CARBINOLS FROM ACHIRAL KETONES
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SARSHAR, S
[J]. TETRAHEDRON LETTERS, 1991, 32 (47) : 6835 - 6838

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