A PRACTICAL CHEMOENZYMIC ROUTE TO (S)-(-)-PROPRANOLOL

被引：12

作者：

KAIMAL, TNB

PRASAD, RBN

RAO, TC

机构：

[1] Indian Institute of Chemical Technology, Hyderabad

来源：

BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 01期

关键词：

D O I：

10.1007/BF01030908

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A practical and economical (compared to methods employing chiral epichlorohydrin) synthesis of the beta-blocker (S)-propranolol [1-isopropylamino-3(1-naphthyloxy)-2-propanol] starting from 2-0-acetyl-1,3-dichloropropanol, 1,3-dichloropropanol or epichlorohydrin has been achieved with the enzymic resolution of the epoxy intermediate (1) as the key step.

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页码：21 / 26

页数：6

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