A PRACTICAL CHEMOENZYMIC ROUTE TO (S)-(-)-PROPRANOLOL

被引:12
作者
KAIMAL, TNB
PRASAD, RBN
RAO, TC
机构
[1] Indian Institute of Chemical Technology, Hyderabad
关键词
D O I
10.1007/BF01030908
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A practical and economical (compared to methods employing chiral epichlorohydrin) synthesis of the beta-blocker (S)-propranolol [1-isopropylamino-3(1-naphthyloxy)-2-propanol] starting from 2-0-acetyl-1,3-dichloropropanol, 1,3-dichloropropanol or epichlorohydrin has been achieved with the enzymic resolution of the epoxy intermediate (1) as the key step.
引用
收藏
页码:21 / 26
页数:6
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