ONLINE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE HYBRIDS USING SILICA SUPPORTS

被引：56

作者：

TRUFFERT, JC

LORTHIOIR, O

ASSELINE, U

THUONG, NT

BRACK, A

机构：

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85218-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure for the preparation of oligonucleotide-peptide hybrid molecules by means of automated synthesis is described. The conjugates have been assembled on silica supports including CPG (Controlled Pore Glass) and Fractosil supports. The novel N-epsilon-lysine protecting group, 1-(3,4-dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl (Dde) was used.

引用

页码：2353 / 2356

页数：4

共 15 条

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