EFFICIENT REGIOSELECTIVE SYNTHESIS OF GUANOSINE ANALOGS

被引:24
作者
JENNY, TF [1 ]
BENNER, SA [1 ]
机构
[1] SWISS FED INST TECHNOL,ORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND
关键词
NUCLEOSIDE ANALOGS; GUANOSINE ANALOGS; GUANINE DERIVATIVES; ANTIVIRAL NUCLEOSIDES; ANTISENSE NUCLEOTIDES;
D O I
10.1016/S0040-4039(00)61000-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction conditions are presented that allow regioselective introduction (N-9 versus N7) of guanine into sugar analogs under Vorbruggen conditions. Using these conditions, a set of N2-protected guanosine analogs has been prepared with N2-isobutyryl-O6-[2-(p-nitrophenyl)ethyl]guanine (1) as nucleophile. This approach helps solve an important synthetic problem in the preparation of guanosine analogs.
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页码:6619 / 6620
页数:2
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