EFFICIENT REGIOSELECTIVE SYNTHESIS OF GUANOSINE ANALOGS

被引：24

作者：

JENNY, TF ^{[1
]}

BENNER, SA ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,ORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 44期

关键词：

NUCLEOSIDE ANALOGS; GUANOSINE ANALOGS; GUANINE DERIVATIVES; ANTIVIRAL NUCLEOSIDES; ANTISENSE NUCLEOTIDES;

D O I：

10.1016/S0040-4039(00)61000-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction conditions are presented that allow regioselective introduction (N-9 versus N7) of guanine into sugar analogs under Vorbruggen conditions. Using these conditions, a set of N2-protected guanosine analogs has been prepared with N2-isobutyryl-O6-[2-(p-nitrophenyl)ethyl]guanine (1) as nucleophile. This approach helps solve an important synthetic problem in the preparation of guanosine analogs.

引用

页码：6619 / 6620

页数：2

共 14 条

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