SYNTHESIS OF ALPHA-AMINO-ACIDS BY ADDITION OF PUTATIVE AZIDO RADICALS TO ALPHA-METHOXY ACRYLONITRILES DERIVED FROM ALDEHYDES AND KETONES

被引：15

作者：

CLIVE, DLJ

ETKIN, N

机构：

[1] Chemistry Department, University of Alberta, Edmonton

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)77143-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Methoxy acrylonitriles, available from aldehydes and ketones, react with sodium azide in the presence of eerie ammonium nitrate to give azido nitrates; from these compounds, alpha-amino acids are obtained by sequential treatment with sodium acetate in acetic acid and then methanolic potassium carbonate, followed by hydrogenation.

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页码：2459 / 2462

页数：4

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