INTERLEUKIN-6 GENE TRANSCRIPTS ARE EXPRESSED IN ATHEROSCLEROTIC LESIONS OF GENETICALLY HYPERLIPIDEMIC RABBITS

被引：80

作者：

IKEDA, U ^{[1
]}

IKEDA, M ^{[1
]}

SEINO, Y ^{[1
]}

TAKAHASHI, M ^{[1
]}

KANO, S ^{[1
]}

SHIMADA, K ^{[1
]}

机构：

[1] JICHI MED SCH,DEPT CLIN IMMUNOL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

ATHEROSCLEROSIS | 1992年 / 92卷 / 2-3期

关键词：

IL-6; INSITU HYBRIDIZATION; WHHL RABBIT;

D O I：

10.1016/0021-9150(92)90280-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the involvement of interleukin 6 (IL-6), a growth-regulatory molecule for vascular smooth muscle cells (SMC), in the development of atherosclerotic lesions of Watanabe heritable hyperlipidemic (WHHL) rabbits. In in situ hybridization analysis, quite low levels of IL-6 mRNA were expressed in 'quiescent' SMC cultured from WHHL rabbits; however, high levels of IL-6 mRNA were induced in SMC exposed to 10% fetal bovine serum (FBS), suggesting that growth-stimulated SMC themselves can synthesize IL-6. In in vivo WHHL aortae, transcripts for the IL-6 gene were clearly observed in the fibrous plaques. These findings support the premise that IL-6 is an important autocrine and/or paracrine regulator of SMC proliferation and of pathogenesis of atherosclerosis in this animal model.

引用

页码：213 / 218

页数：6

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