ALLELE-SPECIFIC GENE PROBING SUPPORTS THE DQ MOLECULE AS A DETERMINANT OF INHERITED SUSCEPTIBILITY TO TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS

被引：31

作者：

JENKINS, D

MIJOVIC, C

JACOBS, KH

PENNY, MA

FLETCHER, J

BARNETT, AH

机构：

[1] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

DIABETOLOGIA | 1991年 / 34卷 / 02期

基金：

英国惠康基金;

关键词：

TRANSRACIAL STUDIES; NORTH INDIANS; GENE PROBING; HLA-DQ; TYPE-1 (INSULIN-DEPENDENT) DIABETES;

D O I：

10.1007/BF00500381

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of inherited protection against Type 1 diabetes (RR = 0.12, p(c) < 0.05). The A3 allele of the DQA1 gene was positively associated with the disease, (RR = 3.6, p(c) < 0.05), as was the DQw2 allele of the DQB1 gene (RR = 4.6, p(c) < 0.01). Trans-racial comparison of these disease associations indicates that DQ alleles may directly determine an element of inherited susceptibility to Type 1 diabetes.

引用

收藏

页码：109 / 113

页数：5

相关论文

共 24 条

[1] HLA-DQ SYSTEM AND INSULIN-DEPENDENT DIABETES-MELLITUS IN JAPANESE - DOES IT CONTRIBUTE TO THE DEVELOPMENT OF IDDM AS IT DOES IN CAUCASIANS [J].

APARICIO, JMR ;

WAKISAKA, A ;

TAKADA, A ;

MATSUURA, N ;

AIZAWA, M .

IMMUNOGENETICS, 1988, 28 (04) :240-246

[2] HIGH-FREQUENCY OF ASPARTIC-ACID AT POSITION-57 OF HLA-DQ BETA-CHAIN IN JAPANESE IDDM PATIENTS AND NONDIABETIC SUBJECTS [J].

AWATA, T ;

KUZUYA, T ;

MATSUDA, A ;

IWAMOTO, Y ;

KANAZAWA, Y ;

OKUYAMA, M ;

JUJI, T .

DIABETES, 1990, 39 (02) :266-269

[3] ANALYSIS OF HLA-DQ GENOTYPES AND SUSCEPTIBILITY IN INSULIN-DEPENDENT DIABETES-MELLITUS [J].

BAISCH, JM ;

WEEKS, T ;

GILES, R ;

HOOVER, M ;

STASTNY, P ;

CAPRA, JD .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (26) :1836-1841

[4] NOMENCLATURE FOR FACTORS OF THE HLA SYSTEM, 1989 [J].

BODMER, JG ;

MARSH, SGE ;

PARHAM, P ;

ERLICH, HA ;

ALBERT, E ;

BODMER, WF ;

DUPONT, B ;

MACH, B ;

MAYR, WR ;

SASAZUKI, T ;

SCHREUDER, GMT ;

STROMINGER, JL ;

SVEJGAARD, A ;

TERASAKI, PI .

TISSUE ANTIGENS, 1990, 35 (01) :1-8

[5] A HYPOTHETICAL MODEL OF THE FOREIGN ANTIGEN-BINDING SITE OF CLASS-II HISTOCOMPATIBILITY MOLECULES [J].

BROWN, JH ;

JARDETZKY, T ;

SAPER, MA ;

SAMRAOUI, B ;

BJORKMAN, PJ ;

WILEY, DC .

NATURE, 1988, 332 (6167) :845-850

[6] CLASS II HLA DNA POLYMORPHISMS IN TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS OF NORTH INDIAN ORIGIN [J].

FLETCHER, J ;

ODUGBESAN, O ;

MIJOVIC, C ;

MACKAY, E ;

BRADWELL, AR ;

BARNETT, AH .

DIABETOLOGIA, 1988, 31 (06) :343-350

[7]

FLETCHER J, 1988, DIABETOLOGIA, V31, P864

[8] GENERATION OF SINGLE-STRANDED-DNA BY THE POLYMERASE CHAIN-REACTION AND ITS APPLICATION TO DIRECT SEQUENCING OF THE HLA-DQA LOCUS [J].

GYLLENSTEN, UB ;

ERLICH, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7652-7656

[9] IDENTIFICATION OF SUSCEPTIBILITY LOCI FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES BY TRANSRACIAL GENE-MAPPING [J].

JENKINS, D ;

MIJOVIC, C ;

FLETCHER, J ;

JACOBS, KH ;

BRADWELL, AR ;

BARNETT, AH .

DIABETOLOGIA, 1990, 33 (07) :387-395

[10] A COMBINATION OF HLA-DQ-BETA ASP57-NEGATIVE AND HLA DQ-ALPHA ARG52 CONFERS SUSCEPTIBILITY TO INSULIN-DEPENDENT DIABETES-MELLITUS [J].

KHALIL, I ;

DAURIOL, L ;

GOBET, M ;

MORIN, L ;

LEPAGE, V ;

DESCHAMPS, I ;

PARK, MS ;

DEGOS, L ;

GALIBERT, F ;

HORS, J .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) :1315-1319