TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION

被引:165
作者
ROTHE, J [1 ]
GEHR, G [1 ]
LOETSCHER, H [1 ]
LESSLAUER, W [1 ]
机构
[1] F HOFFMANN LA ROCHE & CO LTD,BLDG 15,ROOM 6,CH-4002 BASEL,SWITZERLAND
关键词
TUMOR NECROSIS FACTOR; RECEPTORS AND INHIBITORY PROTEINS; NERVE GROWTH FACTOR RECEPTOR FAMILY; CYTOKINES;
D O I
10.1007/BF02918612
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor necrosis factors (TNFs) have been a focus of research for well over a decade now. The identification and recent molecular cloning of two different types of cell-surface TNF receptors will shed further light on the mode of action of these pleiotropic cytokines. In the present article, we summarize the data on the biochemistry and structure of the receptors and focus on the molecular cloning of the respective cDNAs. The nucleotide sequences of the receptor genes revealed that both TNF receptors belong to the still growing nerve growth factor receptor gene family. The function and origin of TNF inhibitory proteins as well as receptor-mediated signal transduction are discussed.
引用
收藏
页码:81 / 90
页数:10
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