THE NUCLEAR GENOMES OF AFRICAN AND AMERICAN TRYPANOSOMES ARE STRIKINGLY DIFFERENT

被引：10

作者：

MUSTO, H

RODRIGUEZMASEDA, H

BERNARDI, G

机构：

[1] INST JACQUES MONOD,GENET MOLEC LAB,F-75005 PARIS,FRANCE

[2] FAC CIENCIAS MONTEVIDEO,DEPT BIOQUIM,MONTEVIDEO 11200,URUGUAY

[3] FAC MED MONTEVIDEO,DEPT GENET,MONTEVIDEO,URUGUAY

来源：

GENE | 1994年 / 141卷 / 01期

关键词：

CODON USAGE; GENOME COMPARTMENTALIZATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA-CRUZI;

D O I：

10.1016/0378-1119(94)90128-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have investigated the compositional distributions of exons and their different codon positions, as well as the codon usage and amino-acid (aa) composition of the nuclear genomes of the African and American trypanosomes Trypanosoma brucei and T. cruzi. Very large differences between the two species were found in all the properties investigated. The most striking differences concern the compositional distributions of third codon positions and the extremely large nucleotide divergence of third codon position for homologous genes encoding proteins that are highly conserved in their aa sequences. Moreover, if coding sequences from each species are divided into two groups according to the GC levels in third codon positions, very different codon usages and aa compositions are found. This indicates a compositional compartmentalization in both genomes which had previously been detected in T. brucei (and T. equiperdum) by compositional fractionation.

引用

页码：63 / 69

页数：7

共 31 条

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