LONG-TERM FOLLOW-UP OF CEREBRAL INFARCTION PATIENTS WITH PROTON MAGNETIC-RESONANCE SPECTROSCOPY

被引:76
作者
GIDEON, P
SPERLING, B
ARLIENSOBORG, P
OLSEN, TS
HENRIKSEN, O
机构
[1] UNIV COPENHAGEN, HVIDOVRE HOSP, DEPT NEUROL, DK-2650 HVIDOVRE, DENMARK
[2] UNIV COPENHAGEN, DK-1168 COPENHAGEN, DENMARK
[3] UNIV COPENHAGEN, BISPEBJERG HOSP, DEPT CLIN PHYSIOL & NUCL MED, DK-1168 COPENHAGEN, DENMARK
[4] UNIV COPENHAGEN, BISPEBJERG HOSP, DEPT NEUROL, DK-1168 COPENHAGEN, DENMARK
关键词
CEREBRAL BLOOD FLOW; CEREBRAL INFARCTION; METABOLISM; SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; STROKE ASSESSMENT;
D O I
10.1161/01.STR.25.5.967
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose With proton magnetic resonance spectroscopy it is possible to measure the content of various brain metabolites in vivo, including N-acetylaspartate (which may be used as a neuronal marker), creatine, choline, and lactate. The content of these brain metabolites was measured serially from the acute stage to the chronic stage of infarction. Regional cerebral blood flow was also measured within the affected areas. These factors were compared with the clinical outcome. Methods Six patients with ischemic stroke were examined serially from the acute stage (less than or equal to 2 days) to the chronic stage (>6 months) with proton magnetic resonance spectroscopy. Cerebral blood flow was measured with single-photon emission-computed tomography with Tc-99m-labeled d,l-hexamethyl-enepropyleneamine oxime as flow tracer. Results Lactate was found in all patients in the acute stage of stroke. Lactate was also found in the 3 largest lesions in the chronic stage; in 2 of these patients lactate was not found in the subacute stage. Reduced levels of N-acetylaspartate were found in 5 patients; in the sixth patient with a small lesion no reduction was found. In all lesions reduced blood flow was found in the acute and chronic stage, whereas hyperemia was found in 4 patients in the subacute stage. Conclusions In this preliminary study no clear correlation was found between the level of N-acetylaspartate or lactate in the acute stage of stroke and the clinical outcome; however, there does appear to be some connection between the reduction of cerebral blood flow and the spectroscopic findings in the chronic stage and to some extent the clinical outcome. Studies of larger clinical groups will be necessary to further elucidate the prognostic potential of proton magnetic resonance spectroscopy in human stroke.
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收藏
页码:967 / 973
页数:7
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