REDUCTIVE BIOTRANSFORMATIONS OF ORGANIC-COMPOUNDS BY CELLS OR ENZYMES OF YEAST

被引:132
作者
WARD, OP
YOUNG, CS
机构
[1] Department of Biology, University of Waterloo, Waterloo, Ont.
基金
加拿大自然科学与工程研究理事会;
关键词
Biotransformation; carbonyl reduction; chiral synthesis; oxidoreductases; S; cerevisiae;
D O I
10.1016/0141-0229(90)90063-V
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Saccharomyces cerevisiae catalyses the asymmetric reductive biotransformation of a variety of compounds containing a carbonyl group or carbon-carbon double bond. Oxidoreductases participating in these reactions which have commercial potential in biotransformation processes are likely to have relatively broad substrate specificity. Important carbonyl reductases falling into this category include YADH- and yeast NADP-dependent β-ketoester reductases. The enoyl reductase component of the FAS complex may have a role in asymmetric yeast reduction of carbon-carbon double bonds of unnatural substrates. Other nicotinamide-requiring oxidoreductases of yeast are also surveyed to rationalize observed biotransformations of whole yeast cells in terms of specific enzymes. Genetic and protein engineering may enable enzymes to be tailored to accept new substrates. A greater understanding of the enzymes and reactions involved will facilitate further optimization and exploitation of these catalytic systems in industrial processes. © 1990.
引用
收藏
页码:482 / 493
页数:12
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