TRANS-1,3-DITHIANE-1,3-DIOXIDE, A NEW CHIRAL ACYL ANION EQUIVALENT FOR THE PREPARATION OF MASKED ACTIVATED ACIDS - APPLICATION TO THE SYNTHESIS OF ALPHA-HYDROXY ACID-DERIVATIVES

被引：34

作者：

AGGARWAL, VK

THOMAS, A

FRANKLIN, RJ

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 14期

关键词：

D O I：

10.1039/c39940001653

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

trans-1,3-Dithiane-1,3-dioxide reacts with high diastereoselectivity with aromatic aldehydes and the 1,3-dithiane-1,3-dioxide moiety can be easily converted to a thiolester without racemisation by carrying out a Pummerer reaction; the thiolester is a group that can be readily transformed into acids, esters, amides, ketones and aldehydes.

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页码：1653 / 1654

页数：2

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