EFFECT OF STREPTOZOTOCIN ON CARNITINE AND CARNITINE ACYLTRANSFERASES IN RAT-HEART, LIVER, AND KIDNEY

被引：27

作者：

FOGLE, PJ

BIEBER, LL

机构：

[1] Department of Biochemistry, Michigan State University, East Lansing

来源：

BIOCHEMICAL MEDICINE | 1979年 / 22卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-2944(79)90044-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes was induced in male rats by a single intravenous injection of streptozotocin. Fourteen days after injection, elevated plasma levels of glucose, β-hydroxybutyrate, and acetoacetate were observed. Specific activities of carnitine acetyl-, octanyl-, isobutyryl-, isovaleryl-, and palmityltransferase were elevated in the 500g supernatants of liver of the streptozotocin-treated animals. In 500g supernatants of kidney, all except the isovaleryltransferase were elevated; in heart, no changes in enzyme levels were observed. Free carnitine, short-chain acylcarnitine, and long-chain acylcarnitine levels were elevated in liver; whereas free carnitine was depressed in heart, and short-chain and long-chain acylcarnitine were elevated in kidney. © 1979.

引用

页码：119 / 126

页数：8

共 18 条

[1] CARNITINE LEVELS IN HUMAN-SERUM IN HEALTH AND DISEASE [J].