GENETIC-MAP OF 8 MICROSATELLITE MARKERS COMPRISING 2 LINKAGE GROUPS ON RAT CHROMOSOME-6

被引：5

作者：

DU, Y ^{[1
]}

REMMERS, EF ^{[1
]}

ZHA, H ^{[1
]}

GOLDMUNTZ, EA ^{[1
]}

MATHERN, P ^{[1
]}

CROFFORD, LJ ^{[1
]}

SZPIRER, J ^{[1
]}

SZPIRER, C ^{[1
]}

WILDER, RL ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,DEPT MOLEC BIOL,RHODE ST GENESE,BELGIUM

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 68卷 / 1-2期

关键词：

D O I：

10.1159/000133901

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Five genes and three anonymous DNA loci were mapped to rat chromosome 6 by genetic linkage and somatic cell hybrid analyses. The eight loci were all identified by PCR-based microsatellite polymorphism analysis and were characterized in 40 F-2 intercross progeny of Fischer (F344/N) and Lewis (LEW/N) inbred rats for segregation analysis. These markers formed two linkage groups spanning, respectively, 58.1 cM and 4.0 cM. The first linkage group is comprised of two anonymous DNA loci and four genes with the following map order and distances: D6Cep8 (previously D3)-17.9 cM-D6Arb309-2.5 cM-Vsnl1 (neural visinin-like protein)-20.4 cM-Prkar2b (type II beta regulatory subunit of cAMP-dependent protein kinase)-8.8 cM-Fkhl1 (forkhead-like transcription factor BF-1)-8.5 cM-Rnu1c(18-3A U1 RNA). The second linkage group is comprised of one gene, Ckb (creatine kinase, brain) and one anonymous DNA locus, D6Arb54, separated by 4.0 cM. For each marker, two to eight alleles were detected in a panel of 16 inbred rat strains (ACI/N, BN/SsN, BUF/N, DA/Bk1, F344/N, LER/N, LEW/N, LOU/MN, MNR/N, MR/N, SHR/N, SR/Jr, SS/Jr, WBB1/N, WBB2/N, and WKY/N). Comparative mapping information indicated that rat chromosome 6 exhibits syntenic conservation with mouse chromosome 12. Homologs of the rat chromosome 6 loci have been identified on human chromosomes 2, 7, and 14.

引用

页码：107 / 111

页数：5

共 20 条

[11] THE GENE MAP OF THE NORWAY RAT (RATTUS-NORVEGICUS) AND COMPARATIVE MAPPING WITH MOUSE AND MAN [J].

LEVAN, G ;

SZPIRER, J ;

SZPIRER, C ;

KLINGA, K ;

HANSON, C ;

ISLAM, MQ .

GENOMICS, 1991, 10 (03) :699-718

[12] COMPUTERIZED ESTIMATION OF SIZE OF NUCLEIC-ACID FRAGMENTS USING THE 4-PARAMETER LOGISTIC MODEL [J].

OERTER, KE ;

MUNSON, PJ ;

MCBRIDE, WO ;

RODBARD, D .

ANALYTICAL BIOCHEMISTRY, 1990, 189 (02) :235-243

[13] GENETIC-MAP OF 9 POLYMORPHIC LOCI COMPRISING A SINGLE LINKAGE GROUP ON RAT CHROMOSOME-10 - EVIDENCE FOR LINKAGE CONSERVATION WITH HUMAN CHROMOSOME-17 AND MOUSE CHROMOSOME-11 [J].

REMMERS, EF ;

GOLDMUNTZ, EA ;

CASH, JM ;

CROFFORD, LJ ;

MISIEWICZPOLTORAK, B ;

ZHA, HB ;

WILDER, RL .

GENOMICS, 1992, 14 (03) :618-623

[14]

SERIKAWA T, 1992, GENETICS, V131, P701

[15] ASSIGNMENT OF THE CHROMOGRANIN-A (CHGA) LOCUS TO HOMOLOGOUS REGIONS ON MOUSE CHROMOSOME-12 AND RAT CHROMOSOME-6 [J].

SIMONCHAZOTTES, D ;

WU, HJ ;

PARMER, RJ ;

ROZANSKY, DJ ;

SZPIRER, J ;

LEVAN, G ;

KURTZ, TW ;

SZPIRER, C ;

GUENET, JL ;

OCONNOR, DT .

GENOMICS, 1993, 17 (01) :252-255

[16] MAPPING OF THE REGULATORY SUBUNITS RI-BETA AND RII-BETA OF CAMP-DEPENDENT PROTEIN-KINASE GENES ON HUMAN CHROMOSOME-7 [J].

SOLBERG, R ;

SISTONEN, P ;

TRASKELIN, AL ;

BERUBE, D ;

SIMARD, J ;

KRAJCI, P ;

JAHNSEN, T ;

DELACHAPELLE, A .

GENOMICS, 1992, 14 (01) :63-69

[17] GENE-MAPPING IN THE RAT BY MOUSE-RAT SOMATIC-CELL HYBRIDIZATION - SYNTENY OF THE ALBUMIN AND ALPHA-FETOPROTEIN GENES AND ASSIGNMENT TO CHROMOSOME-14 [J].

SZPIRER, J ;

LEVAN, G ;

THORN, M ;

SZPIRER, C .

CYTOGENETICS AND CELL GENETICS, 1984, 38 (02) :142-149

[18] A RAT GENETIC-LINKAGE MAP AND COMPARATIVE MAPS FOR MOUSE OR HUMAN HOMOLOGOUS RAT GENES [J].

YAMADA, J ;

KURAMOTO, T ;

SERIKAWA, T .

MAMMALIAN GENOME, 1994, 5 (02) :63-83

[19] LINKAGE MAP OF 10 POLYMORPHIC MARKERS ON RAT CHROMOSOME-2 [J].

ZHA, H ;

WILDER, RL ;

GOLDMUNTZ, EA ;

CASH, JM ;

CROFFORD, LJ ;

MATHERN, P ;

REMMERS, EF .

CYTOGENETICS AND CELL GENETICS, 1993, 63 (02) :117-122

[20]

1991, GDB HUMAN GENOME DAT

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