ANTIBODY ENGINEERING AND PERSPECTIVES IN THERAPY

被引：7

作者：

LEFRANC, G ^{[1
]}

LEFRANC, MP ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2, IMMUNOGENET MOLEC LAB,CNRS,URA 1191, PL E BATAILLON, F-34095 MONTPELLIER 5, FRANCE

来源：

BIOCHIMIE | 1990年 / 72卷 / 09期

关键词：

chimeric antibody; genetic engineering; homologous recombination; immunoadhesin; immunoglobulin; immunotoxin;

D O I：

10.1016/0300-9084(90)90046-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Techniques of genetic engineering, homologous recombination, and gene transfection make it feasible to produce antigen-binding molecules with widely varying structures. Novel proteins which possess the binding specificity of antibody associated with sequences such as an enzyme or toxin have potential use in immunoassays, in imaging, in immunotherapy. Antibody fusion proteins can also be used as a means to purify proteins or to study the function of surface protooncogenes. This paper reviews the recent data on the obtention and utilisation of the genetically engineered antibody molecules, as well as the approach which consists on the expression in vitro, in Escherichia coli, of a practically unlimited repertoire of Fab fragments and antibody sites. © 1990.

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页码：639 / 651

页数：13

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