DETERMINATION OF THE INVIVO KM AND VMAX OF A DRUG WITH TRACER STUDIES

被引：4

作者：

BROWNE, TR

GREENBLATT, D

EVANS, JE

EVANS, BA

SZABO, GK

SCHUMACHER, GE

机构：

[1] EUNICE KENNEDY SHRIVER CTR,MASS SPECTROMETRY LAB,WALTHAM,MA

[2] TUFTS UNIV,SCH MED,DIV CLIN PHARMACOL,BOSTON,MA 02111

[3] NORTHEASTERN UNIV,COLL PHARM & ALLIED HLTH PROFESS,BOSTON,MA 02115

[4] NEW ENGLAND MED CTR,BOSTON,MA 02111

[5] BOSTON UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BOSTON,MA 02118

[6] BOSTON UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02118

[7] VET ADM MED CTR JAMAICA PLAIN,NEUROL SERV 127,BOSTON,MA 02130

[8] TUFTS UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02111

[9] TUFTS UNIV,SCH MED,DEPT MED,BOSTON,MA 02111

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1987年 / 27卷 / 04期

关键词：

D O I：

10.1002/j.1552-4604.1987.tb03023.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：321 / 324

页数：4

共 15 条

[1] BROWN T, 1983, EPILEPSY, P175
[2] STUDIES WITH STABLE ISOTOPES .3. PHARMACOKINETICS OF TRACER DOSES OF DRUG
BROWNE, TR
GREENBLATT, DJ
HARMATZ, JS
EVANS, JE
SZABO, GK
EVANS, BA
SCHUMACHER, GE
[J]. JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 25 (01) : 59 - 63
[3] STUDIES WITH STABLE ISOTOPES .1. CHANGES IN PHENYTOIN PHARMACOKINETICS AND BIOTRANSFORMATION DURING MONOTHERAPY
BROWNE, TR
EVANS, JE
SZABO, GK
EVANS, BA
GREENBLATT, DJ
SCHUMACHER, GE
[J]. JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 25 (01) : 43 - 50
[4] KINETIC EQUIVALENCE OF STABLE-ISOTOPE-LABELED AND UNLABELED PHENYTOIN
BROWNE, TR
VANLANGENHOVE, A
COSTELLO, CE
BIEMANN, K
GREENBLATT, DJ
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 29 (04) : 511 - 515
[5] BROWNE TR, 1983, EPILEPSY DIAGNOSIS M, P161
[6] GREENBLATT DJ, 1977, J PHARMACOL EXP THER, V202, P365
[7] INTEGRATED EQUATION TO EVALUATE ACCUMULATION PROFILES OF DRUGS ELIMINATED BY MICHAELIS-MENTEN KINETICS
LAM, G
CHIOU, WL
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1979, 7 (02): : 227 - 232
[8] RATE OF PHENYTOIN ACCUMULATION IN MAN - SIMULATION STUDY
LUDDEN, TM
ALLEN, JP
SCHNEIDER, LW
STAVCHANSKY, SA
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1978, 6 (05): : 399 - 415
[9] COMPARATIVE EVALUATION OF 6 TECHNIQUES FOR DETERMINING THE MICHAELIS-MENTEN PARAMETERS RELATING PHENYTOIN DOSE AND STEADY-STATE SERUM CONCENTRATIONS
MULLEN, PW
FOSTER, RW
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1979, 31 (02) : 100 - 104
[10] STEADY-STATE PLASMA-CONCENTRATIONS AS A FUNCTION OF THE ABSORPTION RATE AND DOSING INTERVAL FOR DRUGS EXHIBITING CONCENTRATION-DEPENDENT CLEARANCE - CONSEQUENCES FOR PHENYTOIN THERAPY
SAWCHUK, RJ
RECTOR, TS
[J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1979, 7 (06): : 543 - 555

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