PERSPECTIVES ON THE DESIGN AND BIOCHEMICAL PHARMACOLOGY OF INHIBITORS OF THYMIDYLATE SYNTHETASE

被引：101

作者：

SANTI, DV ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 02期

关键词：

D O I：

10.1021/jm00176a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：103 / 111

页数：9

共 48 条

[21]

HEIDELBERGER C, 1974, HDB EXPTL PHARMACO 2, V38, P193

[22]

JOHNSON RK, 1978, CANCER RES, V38, P371

[23]

KALMAN TI, 1970, MOL PHARMACOL, V6, P621

[24] METHYLATION OF 4-THIOURIDYLATE 2'-DEOXYURIDYLATE BY THYMIDYLATE SYNTHETASE [J].

KALMAN, TI ;

BLOCH, A ;

SZEKERES, GL ;

BARDOS, TJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 55 (01) :210-217

[25]

KLINE I, 1966, CANCER RES, V26, P848

[26]

LORENSON MY, 1967, J BIOL CHEM, V242, P3332

[27]

MARTIN DS, 1976, P AM ASSOC CANC RES, V17, P130

[28] 5-NITRO-2'-DEOXYURIDYLATE - MECHANISM-BASED INHIBITOR OF THYMIDYLATE SYNTHETASE [J].

MATSUDA, A ;

WATAYA, Y ;

SANTI, DV .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 84 (03) :654-659

[29] 5-NITRO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE IS A POTENT IRREVERSIBLE INHIBITOR OF LACTOBACILLUS-CAESI THYMIDYLATE SYNTHETASE [J].

MERTES, MP ;

CHANG, CTC ;

DECLERCQ, E ;

HUANG, GF ;

TORRENCE, PF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 84 (04) :1054-1059

[30]

NICHOL CA, 1975, ANTINEOPLASTIC IMMUN, P434

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