DETERMINATION OF HYDROXYCHLOROQUINE AND ITS MAJOR METABOLITES IN PLASMA USING SEQUENTIAL ACHIRAL CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：41

作者：

IREDALE, J ^{[1
]}

WAINER, IW ^{[1
]}

机构：

[1] MCGILL UNIV, DEPT ONCOL, MONTREAL H3G 1Y6, QUEBEC, CANADA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 573卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80126-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sequential achiral-chiral high-performance liquid chromatographic system has been developed for the determination of the enantiomers of hydroxychloroquine, (+)-HCQ and (-)-HCQ, and the enantiomers of its three major metabolites, bisdesethylchloroquine, desethylhydroxychloroquine and desethylchloroquine, in plasma. The HCQ was separated from the metabolites and interfering components in the plasma and quantified on a cyano-bonded phase, and the enantiomeric composition determined using a Chiral-AGP chiral stationary phase. The assay was validated and applied to the analysis of a pilot study of the pharmacokinetics of (+)- and (-)-HCQ in rabbits.

引用

页码：253 / 258

页数：6

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