HUMAN T-CELLS RESPOND TO MOUSE MAMMARY-TUMOR VIRUS-ENCODED SUPERANTIGEN - V-BETA RESTRICTION AND CONSERVED EVOLUTIONARY FEATURES

被引:70
作者
LABRECQUE, N
MCGRATH, H
SUBRAMANYAM, M
HUBER, BT
SEKALY, RP
机构
[1] INST RECH CLIN MONTREAL,IMMUNOL LAB,110 AVE PINS O,MONTREAL H2W 1R7,QUEBEC,CANADA
[2] UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL,MONTREAL H3C 3J7,QUEBEC,CANADA
[3] TUFTS UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02111
关键词
D O I
10.1084/jem.177.6.1735
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mouse mammary tumor virus (MMTV)-encoded superantigens (SAGs) influence the murine T cell repertoire and stimulate a strong mixed lymphocyte response in vitro. These SAGs are encoded by the open reading frame of the 3' long terminal repeat of MMTV, termed MMTV SAGs. The T cell response to MMTV SAGs is Vbeta restricted and requires expression of the class II molecules of the major histocompatibility complex (MHC) on the presenting cells. While human T cells respond to bacterial SAGs, it is not known if human T cells or human MHC class II molecules can interact with MMTV SAGs. A fibroblastic cell line expressing the human MHC class II molecule HLA-DR1 and the Mtv-7 sag gene encoding Mls-1 was used to stimulate human T cells. We show here that human T cells efficiently proliferate in response to Mls-1 presented by HLA-DR1. This T cell response was inhibited by mAbs directed against CD4 or MHC class II molecules but not by mAbs specific for CD8 or MHC class I molecules. Moreover, the response to Mls-1 was limited to human T cells expressing a restricted set of T cell receptor Vbeta chains. Human T cells expressing Vbeta12, 13, 14, 15, and 23 were selectively amplified after Mtv-7 sag stimulation. Interestingly, these human Vbetas share the highest degree of homology with the mouse Vbetas interacting with Mls-1. These results show a strong evolutionary conservation of the structures required for the presentation and the response to retrovirally encoded endogenous SAGs, raising the possibility that similar elements operate in humans to shape the T cell repertoire.
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页码:1735 / 1743
页数:9
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