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A NEW METHOD FOR ESTIMATING DERMAL ABSORPTION FROM CHEMICAL-EXPOSURE .2. EFFECT OF MOLECULAR-WEIGHT AND OCTANOL WATER PARTITIONING
被引:91
作者:
BUNGE, AL
CLEEK, RL
机构:
[1] Chemical Engineering and Petroleum Refining Department, Colorado School of Mines, Golden, Colorado
关键词:
DERMAL ABSORPTION;
EXPOSURE ASSESSMENT;
PERCUTANEOUS ABSORPTION;
MATHEMATICAL MODELS;
STRATUM CORNEUM;
PERMEABILITY;
OCTANOL WATER PARTITIONING;
D O I:
10.1023/A:1016242821610
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A new method for estimating dermal absorption including the effects of exposure time and chemistry is described generally in Part 1 of this series. This method accounts for the larger absorption rates during the initial exposure period as well as the hydrophilic barrier which the viable epidermis presents to lipophilic chemicals. A key parameter in this procedure, the ratio of the stratum corneum and epidermis permeabilities (B) depends on molecular weight and octanol-water partitioning. Several approaches for approximating B and its affect on the dermal absorption prediction are discussed here. Generally, the parameter B is only important for highly lipophilic chemicals which also have relatively small molecular weights. When B is important, the recommended prediction for B is based on the Potts and Guy correlation for human stratum corneum permeability.
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页码:88 / 95
页数:8
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