A LARGE OUTBREAK OF ACUTE GASTROENTERITIS ASSOCIATED WITH ASTROVIRUS AMONG STUDENTS AND TEACHERS IN OSAKA, JAPAN

被引：95

作者：

OISHI, I ^{[1
]}

YAMAZAKI, K ^{[1
]}

KIMOTO, T ^{[1
]}

MINEKAWA, Y ^{[1
]}

UTAGAWA, E ^{[1
]}

YAMAZAKI, S ^{[1
]}

INOUYE, S ^{[1
]}

GROHMANN, GS ^{[1
]}

MONROE, SS ^{[1
]}

STINE, SE ^{[1
]}

CARCAMO, C ^{[1
]}

ANDO, T ^{[1
]}

GLASS, RI ^{[1
]}

机构：

[1] CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,VIRAL GASTROENTERITIS SECT,ATLANTA,GA 30333

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 02期

关键词：

D O I：

10.1093/infdis/170.2.439

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In June 1991, a large outbreak of acute nonbacterial gastroenteritis occurred among students and teachers at 10 primary and 4 junior high schools in Katano City, Osaka, Japan. The outbreak affected > 4700 persons, lasted 5 days, and was believed to have been linked to contaminated food from a common supplier. Astrovirus, identified as the etiologic agent, was detected by direct electron microscopy in 10 of 38 fecal samples obtained from patients with diarrhea. Detection was confirmed by solid-phase immune electron microscopy (IEM), EIA, reverse transcription-polymerase chain reaction, and virus isolation in CaCo-2 cells. Several patients who had astrovirus in their stool also demonstrated a significant antibody response to a reference strain of astrovirus by IEM and EIA and to their own isolate by IEM. Astrovirus can be an important agent of epidemic acute nonbacterial gastroenteritis in school-aged children and adults in Japan.

引用

页码：439 / 443

页数：5

共 15 条

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