ENANTIOMERIC EXCESS ANALYSIS OF (2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANONE AND (1S, 2R, 3S)-3-DEUTERIO-2-METHYLCYCLOHEXANOL, THROUGH DEUTERIUM NMR IN A POLYPEPTIDE LYOTROPIC LIQUID-CRYSTAL

被引：5

作者：

CANET, I

COURTIEU, J

DAUPHIN, G

GOURCY, JG

VESCHAMBRE, H

机构：

[1] UNIV PARIS 11,ICMO,CHIM ORGAN STRUCT LAB,URA 1384,F-91405 ORSAY,FRANCE

[2] LAB CHIM ORGAN BIOL,URA 485,F-63177 CLERMONT FERRAND,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 02期

关键词：

D O I：

10.1016/0957-4166(95)00006-B

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Poly-gamma-benzyl-L-glutamate (PBLG) and dichloromethane form a lyotropic liquid crystal which can be used as solvent for enantiomeric excess analysis of molecules containing several stereogenic centers, through deuterium NMR spectroscopy. All isomers of 3-deuterio-2-methylcyclohexanone and of 3-deuterio-2-methylcyclohexanol dissolved in PBLG/CH(2)Cl2 solvents, exhibit different quadrupolar splittings on their deuterium NMR spectra, which allows an accurate determination of their diastereoisomeric and enantiomeric excesses.

引用

页码：333 / 336

页数：4

共 7 条

[1] NEW, AND ACCURATE METHOD TO DETERMINE THE ENANTIOMERIC PURITY OF AMINO-ACIDS BASED ON DEUTERIUM NMR IN A CHOLESTERIC LYOTROPIC LIQUID-CRYSTAL [J].