THE INSULIN SIGNAL AND ITS EFFECTS ON THE PYRUVATE-DEHYDROGENASE COMPLEX IN CIRCULATING LYMPHOCYTES OF OBESE CHILDREN

被引：8

作者：

CURTO, M

PICCININI, M

CERUTTI, F

RABBONE, I

MOSTERT, M

SACCHETTI, C

BRUNO, R

RINAUDO, MT

机构：

[1] UNIV TURIN, DIPARTIMENTI MED & ONCOL SPERIMENTALE SEZ BIOCHIM, I-10126 TURIN, ITALY

[2] UNIV TURIN, DIPARTIMENTI MORFOFISIOL VET, I-10124 TURIN, ITALY

[3] UNIV TURIN, IST CLIN PEDIAT, I-10124 TURIN, ITALY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 05期

关键词：

D O I：

10.1016/0020-711X(92)90021-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Studies have shown that in circulating lymphocytes pyruvate dehydrogenase (PDH) is responsive to insulin. 2. To improve existing knowledge on how insulin influences PDH behaviour, situations in which cell responsiveness to insulin is impaired could be of interest. 3. PDH behaviour in circulating lymphocytes from obese children, with high plasma insulin levels and normal glucose tolerance, was examined. 4. Masking and unmasking processes of insulin receptors on the plasma membrane appear to modulate the enzyme response to insulin.

引用

收藏

页码：831 / 837

页数：7

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