STEREOSELECTIVE ROUTES TO CHIRAL 2-HYDROXY-4-OXO ACIDS AND SUBSTITUTED 2-HYDROXYBUTYROLACTONES USING LACTATE-DEHYDROGENASES

被引：18

作者：

CASY, G ^{[1
]}

机构：

[1] UNIV BRISTOL,CTR MOLEC RECOGNIT,BRISTOL BS8 1TS,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 52期

关键词：

LACTATE DEHYDROGENASE; 2,4-DIOXO ACIDS; 2-HYDROXY-4-OXO ACIDS; 2-HYDROXYBUTYROLACTONES;

D O I：

10.1016/S0040-4039(00)74747-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective reduction 2,4-dioxo acids catalysed by lactate dehydrogenases provides access to 2-hydroxy-4-oxo acids of both S and R configuration. Subsequent diastereoselective chemical reduction affords 4-substituted 2-hydroxybutyrolactones.

引用

页码：8159 / 8162

页数：4

共 17 条

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