DESIGN AND SYNTHESIS OF A DNA-CLEAVING METALLOPEPTIDE

被引：16

作者：

SHULLENBERGER, DF ^{[1
]}

LONG, EC ^{[1
]}

机构：

[1] INDIANA UNIV PURDUE UNIV, DEPT CHEM, 1125 E 38TH ST, INDIANAPOLIS, IN 46205 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80904-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A structured 14-residue peptide containing (1) a proposed intercalative DNA-binding domain consisting of tyrosine residues connected by tandem beta-turns and (2) a redox-active Cu(II)-binding domain was synthesized and shown to readily cleave PHIX174 plasmid DNA under appropriate conditions of activation.

引用

页码：333 / 336

页数：4

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