HIPPEASTRINE SYNTHESIS - A COMBINED BIO-DIOXYGENATION ORGANOIRON CHIRALITY RELAY APPROACH

被引：15

作者：

ASTLEY, ST ^{[1
]}

MEYER, M ^{[1
]}

STEPHENSON, GR ^{[1
]}

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)60339-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regio- and enantioselective preparation of tricarbonyl(eta5-6(S)-endo-methoxy-1(S)-ethoxycyclohexadienyl)iron(1+) hexafluorophosphate(1-) (3, R = OEt), via a biotransformation entry, is described. The optical purity of 3 (R = OEt), which is required as an intermediate for hippeastrine synthesis, was found to be > 98% e.e. by an NMR chiral shift method.

引用

页码：2035 / 2038

页数：4

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