QUINUCLIDINE-BASED NK-1 ANTAGONISTS .1. 3-BENZYLOXY-1-AZABICYCLO[2.2.2]OCTANES

被引：40

作者：

SEWARD, EM ^{[1
]}

SWAIN, CJ ^{[1
]}

MERCHANT, KJ ^{[1
]}

OWEN, SN ^{[1
]}

SABIN, V ^{[1
]}

CASCIERI, MA ^{[1
]}

SADOWSKI, S ^{[1
]}

STRADER, C ^{[1
]}

BAKER, R ^{[1
]}

机构：

[1] MERCK INST THERAPEUT RES,DEPT MOLEC PHARMACOL & BIOCHEM,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80349-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-benzyloxy-derivatives of CP-96,345 has been evaluated and found to have significant affinity for the human NK1 receptor. 3,5-Disubstitution of the benzyl ether has been identified to be essential for high affinity.

引用

页码：1361 / 1366

页数：6

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