THYROID-CANCER AFTER RADIOTHERAPY FOR SKIN HEMANGIOMA IN INFANCY

被引:65
作者
LUNDELL, M
HAKULINEN, T
HOLM, LE
机构
[1] KAROLINSKA HOSP,RADIUMHEMMET,DEPT CANC EPIDEMIOL,S-10401 STOCKHOLM,SWEDEN
[2] FINNISH CANC REGISTRY,STOCKHOLM,SWEDEN
[3] NATL INST PUBL HLTH,STOCKHOLM,SWEDEN
关键词
D O I
10.2307/3579110
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A Swedish cohort of 14,351 infants exposed to ionizing radiation for skin hemangioma was analyzed with respect to thyroid cancer risk. The subjects were irradiated during the period 1920-1959 and radiotherapy was given with beta particles, gamma rays and/or X rays. The mean absorbed dose to the thyroid was 0.26 Gy (range <0.01-28.5 Gy). The cohort was matched with the Swedish Cancer Register for the period 1958-1986. Seventeen thyroid cancers were registered (standardized incidence ratio = 2.28; 95% confidence interval 1.33-3.65), and the mean thyroid absorbed dose in those subjects was 1.07 Gy (range <0.01-4.34 Gy). The effect of different variables on the incidence of thyroid cancer was evaluated with Poisson regression. The excess in thyroid cancer began 19 years after radiotherapy and persisted at least 40 years after irradiation. A statistically significant dose-response relationship was found. The excess relative risk per gray was 4.92 (95% CI 1.26-10.2) and the excess absolute risk was 0.90 x 10(-4) per person-year gray. No significant difference in excess relative or absolute risk could be seen between the sexes.
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页码:334 / 339
页数:6
相关论文
共 14 条
[1]  
[Anonymous], 1990, HLTH EFFECTS EXPOSUR
[2]  
Breslow N. E., 1987, STATISTICAL METHODS, VII
[3]  
FURST CJ, 1987, ACTA ONCOL, V26, P33
[4]   CANCER INCIDENCE AFTER RADIOTHERAPY FOR SKIN HEMANGIOMA - A RETROSPECTIVE COHORT STUDY IN SWEDEN [J].
FURST, CJ ;
LUNDELL, M ;
HOLM, LE ;
SILFVERSWARD, C .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (17) :1387-1392
[5]   RADIUM TREATMENT FOR HEMANGIOMA IN EARLY-CHILDHOOD - RECONSTRUCTION AND DOSIMETRY OF TREATMENTS, 1920-1959 [J].
LUNDELL, M ;
FURST, CJ ;
HEDLUND, B ;
HOLM, LE .
ACTA ONCOLOGICA, 1990, 29 (05) :551-556
[6]  
PAYNE CD, 1987, GLIM SYSTEM RELEASE
[7]   THYROID NEOPLASIA FOLLOWING LOW-DOSE RADIATION IN CHILDHOOD [J].
RON, E ;
MODAN, B ;
PRESTON, D ;
ALFANDARY, E ;
STOVALL, M ;
BOICE, JD .
RADIATION RESEARCH, 1989, 120 (03) :516-531
[8]   DOSE-RESPONSE RELATIONSHIPS FOR RADIATION-INDUCED THYROID-CANCER AND THYROID-NODULES - EVIDENCE FOR THE PROLONGED EFFECTS OF RADIATION ON THE THYROID [J].
SCHNEIDER, AB ;
RON, E ;
LUBIN, J ;
STOVALL, M ;
GIERLOWSKI, TC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (02) :362-369
[9]   THYROID-CANCER AMONG PERSONS GIVEN X-RAY TREATMENT IN INFANCY FOR AN ENLARGED THYMUS GLAND [J].
SHORE, RE ;
HILDRETH, N ;
DVORETSKY, P ;
ANDRESEN, E ;
MOSESON, M ;
PASTERNACK, B .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1993, 137 (10) :1068-1080
[10]   ISSUES AND EPIDEMIOLOGIC EVIDENCE REGARDING RADIATION-INDUCED THYROID-CANCER [J].
SHORE, RE .
RADIATION RESEARCH, 1992, 131 (01) :98-111