STEREOSELECTIVE ANALYSIS OF KETOROLAC IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：23

作者：

HAYBALL, PJ ^{[1
]}

TAMBLYN, JG ^{[1
]}

HOLDEN, Y ^{[1
]}

WROBEL, J ^{[1
]}

机构：

[1] REPATRIAT GEN HOSP,DEPT ANAESTHET & INTENS CARE,DAW PK,SA,AUSTRALIA

来源：

CHIRALITY | 1993年 / 5卷 / 01期

关键词：

KETOROLAC ENANTIOMERS; HPLC; PLASMA CONCENTRATIONS; NONNARCOTIC ANALGESIC; NONOPIATE ANALGESIC; DIASTEREOMERS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS); STEREOSELECTIVE PHARMACOKINETICS;

D O I：

10.1002/chir.530050107

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A high-performance liquid chromatographic (HPLC) analytical method is described for the quantification of the (R)- and (S)-enantiomers of ketorolac when present together in human plasma. The method involves derivatization with thionyl chloride/(S)-1-phenylethylamine and subsequent reversed-phase chromatography of the diastereomeric (S)-1-phenylethylamides of (R)- and (S)-ketorolac. The method is suitable for the analysis of large numbers of plasma samples and has been applied in this report to a pharmacokinetic study of ketorolac enantiomers upon intramuscular administration of racemic drug to a human subject. The limit of quantification for each enantiomer of ketorolac is 50 ng/ml (signal-to-noise ratio > 10).

引用

页码：31 / 35

页数：5

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