INTERACTIONS OF 3 BENZODIAZEPINE RECEPTOR INVERSE AGONISTS WITH ETHANOL IN A PLUS-MAZE TEST OF ANXIETY

被引:54
作者
LISTER, RG
机构
关键词
D O I
10.1016/0091-3057(88)90087-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of RO 15-4513, RO 15-3505 and FG 7142 on the anxiolytic properties of ethanol in mice were investigated using the plus-maze test of anxiety. Before being tested on the plus-maze, the mice were tested in a holeboard apparatus. All three inverse agonists attenuated the reduction in exploration caused by ethanol in the holeboard test. In the plus-maze, only RO 15-4513 and FG 7142, which possess anxiogenic properties when administered alone, attenuated ethanol''s anxiolytic effect. RO 15-3505, which alone had no effect on anxiety, failed to significantly reduce ethanol''s anxiolytic effect. Neither RO 15-4513 nor FG 7142 reduced the increase in the total number of arm entries caused by ethanol. These data indicate that the interaction between ethanol and benzodiazepine receptor ligands depends both on the intrinsic properties of the ligands and the behavior under investigation.
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页码:701 / 706
页数:6
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共 28 条
  • [21] MULTIPLE SITES OF ACTION FOR ANXIOGENIC DRUGS - BEHAVIORAL, ELECTROPHYSIOLOGICAL AND BIOCHEMICAL CORRELATIONS
    PELLOW, S
    FILE, SE
    [J]. PSYCHOPHARMACOLOGY, 1984, 83 (04) : 304 - 315
  • [22] VALIDATION OF OPEN - CLOSED ARM ENTRIES IN AN ELEVATED PLUS-MAZE AS A MEASURE OF ANXIETY IN THE RAT
    PELLOW, S
    CHOPIN, P
    FILE, SE
    BRILEY, M
    [J]. JOURNAL OF NEUROSCIENCE METHODS, 1985, 14 (03) : 149 - 167
  • [23] PIERI L, 1985, British Journal of Pharmacology, V86, p592P
  • [24] POLC P, 1985, BRIT J PHARMACOL, V86, pP465
  • [25] ORAL ETHANOL REINFORCEMENT IN THE RAT - EFFECT OF THE PARTIAL INVERSE BENZODIAZEPINE AGONIST RO15-4513
    SAMSON, HH
    TOLLIVER, GA
    PFEFFER, AO
    SADEGHI, KG
    MILLS, FG
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (03) : 517 - 519
  • [26] PHOTOAFFINITY-LABELING OF BENZODIAZEPINE RECEPTOR PROTEINS WITH THE PARTIAL INVERSE AGONIST [H-3] RO 15-4513 - A BIOCHEMICAL AND AUTORADIOGRAPHIC STUDY
    SIEGHART, W
    EICHINGER, A
    RICHARDS, JG
    MOHLER, H
    [J]. JOURNAL OF NEUROCHEMISTRY, 1987, 48 (01) : 46 - 52
  • [27] A SELECTIVE IMIDAZOBENZODIAZEPINE ANTAGONIST OF ETHANOL IN THE RAT
    SUZDAK, PD
    GLOWA, JR
    CRAWLEY, JN
    SCHWARTZ, RD
    SKOLNICK, P
    PAUL, SM
    [J]. SCIENCE, 1986, 234 (4781) : 1243 - 1247
  • [28] Winer B. J., 1971, STAT PRINCIPLES EXPT, V2